Mentions légales
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| 28.07.2022 | APOEL FC | 2-0 | Botev Plovdiv | |
| 20.07.2022 | Botev Plovdiv | 0-0 | APOEL FC |
| 28.07.2022 | Neftchi Baku | 3-0 | Aris Limassol | |
| 21.07.2022 | Aris Limassol | 2-0 | Neftchi Baku |
| 27.07.2022 | FC Gomel | 1-2 | Aris Salonica | |
| 21.07.2022 | Aris Salonica | 5-1 | FC Gomel |
| 28.07.2022 | FK Tuzla City | 0-4 | AZ Alkmaar | |
| 21.07.2022 | AZ Alkmaar | 1-0 | FK Tuzla City |
| 28.07.2022 | SP Tre Fiori | 0-0 | B36 Torshavn | |
| 21.07.2022 | B36 Torshavn | 1-0 | SP Tre Fiori |
| 28.07.2022 | Konyaspor | 2-0 | BATE Borisov | |
| 21.07.2022 | BATE Borisov | 0-3 | Konyaspor |
| 28.07.2022 | FK Buducnost | 2-1 | Breidablik | |
| 21.07.2022 | Breidablik | 2-0 | FK Buducnost |
| 28.07.2022 | Cukaricki Belgrade | 4-0 | RFCU Luxemburg | |
| 21.07.2022 | RFCU Luxemburg | 1-4 | Cukaricki Belgrade |
| 28.07.2022 | Dinamo Minsk | 0-1 | Hapoel Be'er Sheva | |
| 21.07.2022 | Hapoel Be'er Sheva | 2-1 | Dinamo Minsk |
| 28.07.2022 | Djurgårdens IF | 2-0 | HNK Rijeka | |
| 21.07.2022 | HNK Rijeka | 1-2 | Djurgårdens IF |
| 28.07.2022 | Dunajska Streda | 2-0 | Vikingur Gota | |
| 20.07.2022 | Vikingur Gota | 0-2 | Dunajska Streda |
| 28.07.2022 | Paide Linnameeskond | 0-0/p.5-3 | FC Ararat-Armenia | |
| 21.07.2022 | FC Ararat-Armenia | 0-0 | Paide Linnameeskond |
| 28.07.2022 | Crusaders Belfast | 1-1 | FC Basel | |
| 21.07.2022 | FC Basel | 2-0 | Crusaders Belfast |
| 28.07.2022 | FCSB | 4-2 | FC Iberia 1999 | |
| 21.07.2022 | FC Iberia 1999 | 1-0 | FCSB |
| 28.07.2022 | FC Milsami | 1-4 | KuPS Kuopio | |
| 21.07.2022 | KuPS Kuopio | 2-2 | FC Milsami |
| 28.07.2022 | BSC Young Boys | 3-0 | FK Liepaja | |
| 21.07.2022 | FK Liepaja | 0-1 | BSC Young Boys |
| 28.07.2022 | Gabala FC | 2-1 | Fehervar FC | |
| 21.07.2022 | Fehervar FC | 4-1 | Gabala FC |
| 28.07.2022 | IF Elfsborg | 1-2 | Molde FK | |
| 21.07.2022 | Molde FK | 4-1 | IF Elfsborg |
| 28.07.2022 | Kisvárda FC | 1-0 | Kairat Almaty | |
| 21.07.2022 | Kairat Almaty | 0-1 | Kisvárda FC |
| 28.07.2022 | Lechia Gdansk | 1-2 | Rapid Wien | |
| 21.07.2022 | Rapid Wien | 0-0 | Lechia Gdansk |
| 28.07.2022 | PAOK Salonica | 1-1 | Levski Sofia | |
| 21.07.2022 | Levski Sofia | 2-0 | PAOK Salonica |
| 28.07.2022 | Lillestrom SK | 5-2 | Seinajoen JK | |
| 21.07.2022 | Seinajoen JK | 0-1 | Lillestrom SK |
| 28.07.2022 | Maccabi Netanya | 0-1 | Istanbul Basaksehir | |
| 21.07.2022 | Istanbul Basaksehir | 1-1 | Maccabi Netanya |
| 28.07.2022 | Maccabi Tel Aviv | 0-0 | Zira FK | |
| 21.07.2022 | Zira FK | 0-3 | Maccabi Tel Aviv |
| 28.07.2022 | CSKA Sofia | 4-0 | Makedonija GP | |
| 21.07.2022 | Makedonija GP | 0-0 | CSKA Sofia |
| 28.07.2022 | Sligo Rovers | 2-0 | Motherwell FC | |
| 21.07.2022 | Motherwell FC | 0-1 | Sligo Rovers |
| 28.07.2022 | Mura | 0-0/p.5-6 | St Patrick's Dublin | |
| 21.07.2022 | St Patrick's Dublin | 1-1 | Mura |
| 28.07.2022 | NK Osijek | 0-2 | FK Kyzylzhar | |
| 21.07.2022 | FK Kyzylzhar | 1-2 | NK Osijek |
| 28.07.2022 | KF Laci | 1-4 | Petrocub Hîncești | |
| 21.07.2022 | Petrocub Hîncești | 0-0 | KF Laci |
| 28.07.2022 | Brøndby IF | 4-0 | Pogoń Szczecin | |
| 21.07.2022 | Pogoń Szczecin | 1-1 | Brøndby IF |
| 28.07.2022 | Puskás Akadémia | 0-0 | Vitória Guimarães | |
| 21.07.2022 | Vitória Guimarães | 3-0 | Puskás Akadémia |
| 28.07.2022 | Radnicki Nis | 3-3/p.1-3 | Gzira United | |
| 21.07.2022 | Gzira United | 2-2 | Radnicki Nis |
| 28.07.2022 | Riga FC | 2-1 | MFK Ruzomberok | |
| 21.07.2022 | MFK Ruzomberok | 0-3 | Riga FC |
| 28.07.2022 | Drita FC | 0-2 | Royal Antwerp | |
| 21.07.2022 | Royal Antwerp | 0-0 | Drita FC |
| 28.07.2022 | Olimpija Ljubljana | 2-0/p.2-4 | Sepsi OSK | |
| 21.07.2022 | Sepsi OSK | 3-1 | Olimpija Ljubljana |
| 28.07.2022 | Shkendija'79 | 3-1 | Valmieras FK | |
| 21.07.2022 | Valmieras FK | 1-2 | Shkendija'79 |
| 28.07.2022 | Viking FK | 2-1 | Sparta Praha | |
| 21.07.2022 | Sparta Praha | 0-0 | Viking FK |
| 28.07.2022 | Newtown AFC | 1-2 | Spartak Trnava | |
| 21.07.2022 | Spartak Trnava | 4-1 | Newtown AFC |
| 28.07.2022 | Slavia Praha | 7-0 | St Joseph's (GIB) | |
| 21.07.2022 | St Joseph's (GIB) | 0-4 | Slavia Praha |
| 28.07.2022 | Hamrun Spartans | 1-0 | Velez Mostar | |
| 21.07.2022 | Velez Mostar | 0-1 | Hamrun Spartans |
| 28.07.2022 | Universitatea Craiova | 3-0 | Vllaznia Shkodër | |
| 21.07.2022 | Vllaznia Shkodër | 1-1 | Universitatea Craiova |
| 27.07.2022 | AIK Fotboll | 2-0 AET | Vorskla | |
| 21.07.2022 | Vorskla | 3-2 | AIK Fotboll |