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| 26.02.2022 | |||||
| 19:00 | D1 Regular Season | Philadelphia Union | - | Minnesota United | |
| 21:30 | D1 Regular Season | Columbus Crew | - | Vancouver WC | |
| 21:30 | D1 Regular Season | Los Angeles FC | - | Colorado Rapids | |
| 23:30 | D1 Regular Season | FC Dallas | - | Toronto FC | |
| 27.02.2022 | |||||
| 00:00 | D1 Regular Season | Austin FC | - | FC Cincinnati | |
| 00:00 | D1 Regular Season | DC United | - | Charlotte FC | |
| 00:00 | D1 Regular Season | Inter Miami CF | - | Chicago Fire | |
| 00:00 | D1 Regular Season | San Jose Earthquake | - | New York Red Bulls | |
| 01:30 | D1 Regular Season | Portland Timbers | - | New England Revs | |
| 19:00 | D1 Regular Season | Orlando City SC | - | CF Montréal | |
| 21:00 | D1 Regular Season | Atlanta United | - | Sporting Kansas City | |
| 23:00 | D1 Regular Season | Los Angeles Galaxy | - | New York City FC | |